Journal: Frontiers in Aging Neuroscience
Article Title: Clinically Precedented Protein Kinases: Rationale for Their Use in Neurodegenerative Disease
doi: 10.3389/fnagi.2020.00242
Figure Lengend Snippet: Summary of kinases covered in manuscript with respect to function, disease association, inhibitors, and clinical development.
Article Snippet: Several ATP-competitive inhibitors have been identified with a range of preferences for the δ and ε isoforms, such as the set of molecules from Pfizer which have been demonstrated to exhibit central exposure and target engagement: PF-4800567, PF-0670462, and the PET ligand PF-5236216 ( ; ; , ).
Techniques: Activation Assay, Mouse Assay, Inhibition, Activity Assay, Expressing, Phospho-proteomics, Blocking Assay